SYNTHESIS AND BIOLOGICAL SCREENING OF SOME SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
Pradeep Kumar L.*, Dr. Sangamesh B. Puranik, Dr. Ashok Kumar B. S., Sridhar S. M., Gopisetty Saran
ABSTRACT
Synthesis of commercially available benzimidazole involves condensation of o-phenylenediamine with formic acid. The most prominent Benzimidazole compound in nature is N-riosyl dimethyl benzimidazole. Benzimidazoles are an important class of compounds with a wide spectrum of biological activity like anti-hypertensive, anti-viral, anti-inflammatory, anti-oxidant, anti-fungal, antitumor and anthelmintic. The five membered heterocyclic moiety with substituted amines, aniline, amides also confers for various biological activity. Hence a series of benzimidazole ethanone derivatives fused with phenylhydrazone ring system have been synthesized, characterized by UV,IR and 1HNMR spectral data and evaluated for their in vitro and in vivo anti-inflammatory and antioxidant activity. The substituted benzimdazoles are summarized in this review to know about the chemistry as well as Pharmacological activity.@2012 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND licence (http://creativecommons.org/licenses/by-nc-nd/3.0/).
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