World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

SPIRONOLACTONE INDUCED GYNECOMASTIA- A CASE REPORT

Palanisamy Sharmila Nirojini*, Maddirevula Maneesh Kumar Reddy, Rama Rao Nadendla4 and A. Pramila Rani

ABSTRACT

Gynecomastia is proliferation male breast tissue due to an imbalance in estrogen and androgen action. Though it is rare it causes anxiety, embarrassment and physical discomfort in the affected male. This case report is of a 69-year-old male patient who presented with the symptom of painful swelling in his both breasts. He is suffering from hypothyroidism, type 1 diabetes mellitus and myocardial infarction from past few years and using Eltroxin, Atorvastatin, Aspirin, Clopidogrel, Glimipride and Metformin. He was also diagnosed with clinically controlled Congestive Cardiac Failure (CCF) for which he was prescribed Lasilactone (Furosemide 20mg and Spironolactone 50mg) and developed enlargement of his breast after 9 months of treatment and diagnosed by the physician as bilateral gynecomastia. The physician withdrawn Lasilactone and added Furosemide 40mg. but the poor prognosis of his pedal edema caused by his CCF made the patient to take Lasilactone and the symptoms of gynecomastia recurred again. Diagnosing drug induced gynecomastia and discontinuing the drug causing it will prevent the need of surgery for gynecomastia.

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