A BRIEF REVIEW ON MECHANISM AND ROLE OF HERBAL EXTRACTS IN THE TREATMENT OF CALCIUM OXALATE KIDNEY STONES THROUGH IN-VIVO ANIMAL STUDIES
Arshvir Kaur, Amneet Kaur, Nikhil Saxena, Ashish Kumar, Sujit Bose and Kajol Sharma*
ABSTRACT
Calcium oxalate stones are the major kidney stones as they are the product of the residue of the urinary contents which got precipitated, crystallized, aggregated and reserved in the kidney. The occurrence of these stones depends on certain factors genetics and age. The major term used for kidney stones is ‘Urolithiasis’ and the main allopathic treatment which is available in the market is Allopurinol, Zonisamide. The allopathic drugs are having certain limitation so herbal plants are good sources to overcome this problem. There are so many herbal treatments available for kidney stones like extracts of tulsi, Foeniculum vulgare, etc. Some of them are also tested in the preclinical trials because they do not cause any allergy and tiredness. The present review gives an idea on the various herbal extract that is tested on the animal model and they elimate the growth of the calcium oxalate stones by the various mechanism. This article gives information about the animal model, model for inducing the stones like ethylene glycol, ammonium chloride, etc in the animal model along with the uses of the model.
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