LOBULAR NEOPLASIA: ATYPICAL HYPERPLASIA AND LOBULAR CARCINOMA IN SITU: LITERATURE REVIEW
*Meriem Nadi, Hanane Ouhame, F. Z. Belkouchi, Samir Bargach and Mounia Malki Yousfi
ABSTRACT
Lobular neoplasia pathology is a rare proliferative breast lesion, includes atypical hyperplasia and lobular carcinoma in situ, growing inside ducts and terminal ductolobular units. It represents a marker of increased risk for breast cancer and a non-obligate precursor of malignancy. Evidence available on diagnosis and management is scarce. It is frequently found incidentally associated with other lesions, but can be visible through mammography, ultrasound or magnetic resonance. Due to the risk of underestimation, surgical excision is often performed. The analysis of imaging and histopathological characteristics could help identifying low-risk cases, for which surgery is not necessary. Chemopreventive agents can be used for risk reduction.
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