Abstract

Nitasha Faiz*, Uzma Jabeen and Samina Sadiq

ABSTRACT

Objective: The purpose of this study is to find out the frequency of colonization of by different bacterial pathogens and their antibiotic sensitivity pattern in our setting. Material & Methods: conducted a cross-sectional study at the Multan Institute of Cardiology. The study was conducted over six months from April 2020 to September 2020. Forty-three patients were selected through simple consecutive sampling having indwelling central venous catheters (CVCs). The isolated organisms were identified by standard microbiological procedure and subjected to antimicrobial sensitivity. SPSS-16 was used for statistical analysis. Results: In this study, a total of forty-three Catheter tips were evaluated through microbiological examination. Out of 43 samples, sixteen were found positive, six from peripheral blood and seven from the Tip of the catheter. Three patients had positive cultures both from blood and from the Tip of the catheter showing the same bacteria in both cultures. Remaining samples either had no organism grown or had nominal growth. Out of 43 samples, 16 (37.2%) showed significant growth of an organism. The most common organisms found in the culture were Acinetobacter (SPP) baumannii 5 (31.2%), Staphylococcus aureus 4 (25%), Coagulase Negative Staphylococcus 2 (12.2%), Pseudomonas aeruginosa 3 (18.7%) followed by and Klebsiella pneumonia 1 (6.25%) All five gram positive bacteria were sensitive to Vancomycin (100%) while Imipenim 4 (57%) and Amikacin (8 (50%) were sensitive for gram-negative bacteria Conclusion: The incidence of Catheter-related infection in our hospital was 37.2%. Acinetobacter baumannii was the most common pathogen isolated from culture. Vancomycin and linezolid were sensitive for Gram-positive bacteria, while Imipenim and Amikacin were sensitive for gram-negative bacteria. Piperacillin-tazobactum proved to be a right broad-spectrum antibiotic. Empirical therapy for such infections in health care settings should be used to get a good outcome.