Abstract

K. Dhunmati*, Sandhiya V. and Kousalya M.

ABSTRACT

Objective: The objective of the present study was to synthesize and screen the in-vitro anticancer activity of quinazoline derivative on MCF 7 Cell line. Method: Quinazoline derivatives belonging to the N-containing heterocyclic compounds have caused universal concerns due to their wide and distinct biopharmaceutical activities. The synthesized quinazoline derivatives was screened for anticancer activity against MCF 7 cell line study (via) MTT assay at different concentration level. Result: From the investigation of the study nearly 11 compounds were synthesized out of which two compounds such as 4-(2-fluorophenyl)-1,4,5,6 tetrahydro-2-(methyl thio) benzo quinazoline (C1) and 4-(3,4 dimethoxyphenyl)-1,4,5,6-tetrahydro-2-(methylthio) benzo quinazoline (C2) showed anti cancer activity. Conclusion: From the studies the results reveals that the compound quinazoline derivatives has significant anticancer activity against breast cancer cell line.