Abstract

Anchu C.*, B. Ajith, Dawn V. J. and Sivaranjini S.

ABSTRACT

Background: Metformin is a widely used anti-hyperglycemic agent recommended for Type II Diabetic patients regardless of age. The most serious adverse effect associated with metformin is acknowledged to be lactic acidosis. The objective of the study was assess correlation between Metformin usage and plasma Lactate level of Type II Diabetes mellitus patients in a tertiary care teaching hospital. Method: This was a prospective observational study including 193 patients for a period of 6 months in Government Medical College, Trivandrum. Patients of age ?30 who had type 2 Diabetes Mellitus with all co-morbidities enrolled in this study. The demographic data, disease data and laboratory data fasting plasma lactate was noticed. Pearson correlation was used to assess relationship between metformin and fasting plasma lactate. Results: The study population was predominantly female (59.5%) and nearly a third (59.5%) belonged to the age group of 51-60 years. Pearson correlation coefficient of plasma lactate with duration of metformin therapy was 0.479 the scatter gram indicated that there is a moderate positive relationship between two variables. Plasma lactate concentration increases with increasing duration of metformin therapy. This result was found to be statistically significant at the P value of 0.000 (P