LOCAL EXPRESSION LEVEL OF IL17 & IL4 CYTOKINES REFLECT THEIR ROLE IN THE PATHOGENESIS OF HASHIMOTO’S THYROIDITIS
*Ibrahim A. Altamemi, Thair Wali Ali, Attaa A. Altamimi and Ahmed Kifah Alwayly
ABSTRACT
Hashimoto's thyroiditis, is an autoimmune disease of the thyroid gland characterized by the presence of antibodies directed against the thyroid, and by infiltration of the thyroid gland by lymphocytes. The present study was conducted to investigate the role of IL17 & IL4 cytokines in the pathogenesis of HT in association with disease clinical and pathological feature. Total 46 paraffin embedded section of total thyroidectomy from patients with HT, in addition to 49 with non inflammatory multi-nodular goiter (considered as control group) were included in this study, and collected from Alkindy teaching hospital, all clinical data for each case were collected for each patients, an IHC technique were conducted by using monoclonal antibodies for both Il-17, and Il-4. According to present study the mean cytokine expression in patients with HT was significantly higher than that of control group for both IL-17 and IL-4 (P
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