Abstract

Shraddha Nagpure*

ABSTRACT

The aim of present work was to prepared and characterized Metformin Sublingual tablet by using superdisintegrants to increase the rate of Disintegration and Dissolution. Metformin sublingual tablet is prepared by using 3×3 factorial design. The Superdisintegrants like Cross povidon, Polyvinyl pyrrolidon and Microcrystalline cellulose were used in different concentration in each formulation which increase the bio-availability of formulation. All formulations were prepared by Direct compression method. The prepared F1 formulation is the found to be best formulation among all 9 formulations of improving solubility of drugs and prepared Metformin Sublingual tablets were evaluated for weight variation, thickness, hardness, drug content, disintegration and dissolution rate studies. The F1 formulation was found to be 8 sec of disintegration time and 12 min of dissolution time. The developed sublingual drug delivery of Metformin sublingual tablet was one of the alternative route of administration to improve bioavailability through sublingual mucosa and improve patient compliance.