SEROTONIN PATHWAY INVOLVEMENT IN SUPPRESSED PERCEPTION OF PAIN IN PLANTAIN DIET FED-MICE
*Peter Erigbali, Emily Kiridi and Ebikemefa Donbraye
ABSTRACT
We investigated the involvement of serotonin receptors in the observed suppression of spontaneous perception of pain in mice that consumed unripe plantain diet for 30 consecutive days. Hot plate and formalin tests were used to study A?-fiber and C-fiber responses to pain stimulus in groups of mice that were fed plantain, plantain + ritanserin (serotonin antagonist) or normal rodent chow (control). Serotonin and 5-hydroxytryptamine concentrations in the brains of the mice were measured by High Performance Liquid Chromatography technique at the end of the pain response studies. The result shows that latency of jump was significantly (p
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