Abstract

Rija Qazi, Saher Taj Shiza, Muhammad Awais Jameel, Iram Shahzadi, Huzaifa Ahmer, Kumar Singh and Danyal Babar*

ABSTRACT

Objective: Patients with heart failure may benefit from vitamin D treatment, according to new research. Methods: In our current nonrandomized clinical research, 43 individuals with dilated cardiomyopathy who did not exhibit substantial gains in physical functioning with optimum heart failure therapy were included. Twelve weeks of weekly vitamin D supplements (200,000 IU) were added to the heart failure therapy to help improve the patient's condition. On the other hand, researchers looked at how it affected the 6-minute walk distance and pro-BNP levels. To analyses the data, we utilized SPSS version 19. Accordingly, we utilized random samples t-tests to assess the substantial role of vitamin D supplementation on pre-intervention vitamin D level, 6-minute walk distance, and pro-BNP level, respectively. Significance was defined as an alpha value less than 0.01. Results: Individuals in NYHA class II (66%) were the majority, while those in NYHA classes I, III and IV were represented by 18%, 8% and 5%, accordingly. After a follow-up of 14 weeks, the mean vitamin D level was increased from 17.596 ng/ml at baseline to 32.974 ng/ml (p < 0.0006). Pre-intervention mean distance travelled was 806382 ft, and after follow-up it was 945392 ft with p value of 0.07. While before the intervention, the mean per-BNP level of research participant was 1025-636, and after intervention, it had enhanced to 160-80--a statistically significant improvement with p value of < 0.005. Conclusion: Vitamin D administration decreases the intensity of heart failure, characterized by a decline in the levels of pro-BNP and an increase in the six-minute walk distance.