EFFECT OF SUBCUTANEOUS SEMAGLUTIDE VS. DAILY LIRAGLUTIDE ON BODY WEIGHT IN ADULTS WITH OVERWEIGHT OR OBESITY WITHOUT DIABETES: SYSTEMIC REVIEW AND META-ANALYSIS
Dr. Bashayer Dhaifallah Alanazi*
ABSTRACT
Objectives: To provide an overview understanding and evaluate the efficacy of semaglutide and liraglutide for weight management and loss in adults without diabetes. Methods: Randomized controlled trials studies comparing semaglutide to liraglutide as well as semaglutide to placebo were identified and collected using PubMed. Mean rate differences were extracted from eligible studies and used to synthesize the results. Results: 10 relevant studies with a total sample size of almost 8792 non-diabetic adult patients were included. Both, semaglutide and liraglutide, had a significant effect, however, semagutide had a higher effect on body weight loss than liraglutide. Also, semagutide had a positive effect on body weight loss in non-diabetic obese adults when compared to the control group that were medicated with a placebo medication. Conclusions: Semaglutide 2.4 mg has a higher efficacy in treating obesity in non-diabetic adults. Higher levels semaglutide has higher efficacy than lower levels. Also, semaglutide may be superior to liraglutide when it comes to managing body weight in non-diabetic adults diagnosed with obesity.
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