Abstract

*Ravindra Mishra, *Harsha Rathore, Vinita Kushwah and Dr. Vinay Jain

ABSTRACT

The present study investigates the ANTI-INFLAMMATORY ACTIVITY OF ethanolic extract of H. ROSA SINENSIS & T. CORDIFOLIA PLANTS” using CARRAGEENAN INDUCED PAW EDEMA induced in wistar rats. In traditional medicinal system different parts of the plant have been mentioned to be useful in a variety of diseases. The hibiscus plant material is widely used as a cardiotonic, anti-constipates, anti-hepatoxic agents and plant TINOSPORA is used in the treatment of fever, jaundice, anti-poisoning agents. The flowers of hibiscus and leaves of tinospora are employed for the treatment of inflammation. The objective of the present study was to evaluate the anti-inflammatory activity of both ethanolic extracts of flowers of hibiscus and leaves of Tinospora on carrageenan induced paw edema in rats. Indomethacin used as a standard drug. For this activity Animals were divided into four groups of six animals. Group I served as control (0.9% normal saline, 5 mlkg-1 b.w), Group II and III received extracts at the doses of 100 and 200 mgkg-1 b.w respectively and group IV as standard (Indomethacin 5 mgkg-1 b.w). The result showed the ethanolic extract of Hibiscus rosa sinensis and Tinospora cordifolia exhibited significant anti-inflammatory activity on the tested animals during experiment. In carrageenan induced rat paw oedema there was significant reduction in paw volume in Indomethacin standard group (p