World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF LISINOPRIL IN BULK AND PHARMACEUTICAL DOSAGE FORM

*Kumaraswamy Gandla, Ravinder M., K. Sushimitha, Narmada Gade

ABSTRACT

An accurate, precise and reproducible RP-HPLC method was developed and validated for the estimation of lisinopril in bulk and pharmaceutical dosage form. The chromatographic separation was carried out on Phenomenex column C18 (250x4.6mm,5?m),column by using the mobile phase Acetonitrile:Buffer 0.1M (70:30 % v/v) at a flow rate of 1.0 mL/ min. The detection was carried out at a wave length of 237 nm. The retention time for Lisinopril was found to be 3.444 respectively. The developed method was validated according to ICH guidelines.

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