Abstract

Polatova Djamila Shagayratovna, Madaminov Akhmad Yuldashevich*, Savkin Aleksandr Vladimirovich, Kahharov Alisher Jamаladdinovich, Madaliev Akhror Alievich and Botiralieva Gulrukh Komilzhonovna

ABSTRACT

Background: In addition to chemical carcinogens, an important role is played by the human papillomavirus (HPV), whose prevalence is steadily growing and becoming an epidemic. According to Centers for Disease Control and Prevention about 70% of cases of oropharyngeal squamous cell carcinoma (OPSCC) are caused by HPV. HPV+OPSCC has specific biological and immunological properties and has a significantly better response to treatment and higher overall survival compared. Methods: The study included 62 patients treated with OPSCC T1-4N0-3M0 (7th edition, AJCC) in 2015-2020 in clinics located in two large cities of Uzbekistan (Tashkent and Samarkand). All patients (n=62) underwent IHC analysis for p16INK4a, PD-L1 and p53 proteins in formalin-fixed paraffin embedding tumor tissue samples. The p16INK4a IHC was the only HPV status test that was interpreted according to the recommendations of the College of American Pathologists. There is a subgroup of patients with HPV+OPSCC with a tendency to relapse, which leads to discrimination of disease outcomes. Results: Positive expression of PD-L1 improved overall survival compared to negative expression (p = 0.261) in HPV-positive OPSCC (p=0.261). In all cases, a negative correlation was observed between p53mutant and HPV status (p