A SYSTEMATIC REVIEW OF PATHOPHYSIOLOGY, CLINICAL PRESENTATION, TYPES AND TREATMENT OF PSORIASIS
Neha Kushwaha, Monika Rai, Basant Khare*, Prateek Kumar Jain and Anushree Jain
ABSTRACT
Psoriasis is a chronic, multisystem inflammatory disease with predominantly skin and joint involvement. It has a bimodal age of onset (16 to 22 and 57 to 60 years)2 and affects both sexes equally. Beyond the physical dimensions of disease, psoriasis has an extensive emotional and psychosocial effect on patients, affecting social functioning and interpersonal relationships. As a disease of systemic inflammation, psoriasis is associated with multiple comorbidities, including cardiovascular disease and malignancy. The diagnosis is primarily clinical and a skin biopsy is seldom required. Depending on the severity of disease, appropriate treatment can be initiated. For mild to moderate disease, first-line treatment involves topical therapies including corticosteroids, vitamin D3 analogues, and combination products. In this review we have discussed about, etiology, pathophysiology, types, diagnostic methods and available treatment strategies for Psoriasis.
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