REVIEW ON RESEALED ERYTHROCYTES AS A NOVEL DRUG DELIVERY SYSTEMS
Pavan Sawant*, Tejas Sapre, Jayesh Sawant and Babasaheb Bhagat
ABSTRACT
Cellular carriers possess great potential in novel drug delivery systems. Among such cellular carriers, erythrocytes have been found to contain enormous merits for targeted and controlled drug delivery systems. Erythrocyte carriers are nanodevices in the field of nanotechnology.Erythrocytes are also known as RBCs. The compatibility with biological,anti-pathogen,anti-immunogenicity and ability to decompose make them unique and beneficial carriers. These carriers are prepared by collecting the blood sample from the organism by separating red blood cells from plasma, entrapping the drug in red blood cells and resealing the obtained cellular carriers, which are called resealed erythrocytes. Erythrocytes are prepared using methods like hypotonic dilution, hypotonic dialysis, pre-swelling, osmotic lysis, perturbation, and lipid fusion.Presents articles give information about introduction, properties, advantages and disadvantages, composition, isolation, drug loading methods, evaluation, application and novel approaches of resealed erythrocytes.
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