Abstract

Mahesh V. Dhamane*, Priyanka A. Dhakane and Dr. Smita A. Merekar

ABSTRACT

Today is the world of the computer technology and it is widely used in the pharmaceutical industry also. The drug development and discovery of the new drug is the very time taking process.[1,2] For the development of the new drug it takes a time up to 12-15 years. For the development of the new drug the investors invest the money in large amount but he cannot confident about the success of the development of new drug for to avoid the wastage of the money the predevelopment techniques are used to study the properties of the drug. At the beginning of the industrial development the predevelopment property of the drug are studied by using the laboratories methods but in the modern word the computerized technology are used in the study of the new drug molecule.[3,4] For the prediction of the new drug hypothesis the in vivo and in vitro methods are used at the beginning but at this new generation of the modern drug designing and development of the new drug the computerized methods are used.[6,7] Recently, a trend towards the use of in-silico method is used for the modeling for the computer aided drug designing. There are different techniques used in in-silico drug designing visualization, homology, molecular dynamic, molecular docking, energy minimization and QSAR etc. in in silico drug design can take part considerable in all stages of drug development from the preclinical discovery stage to late stage clinical development. This review gives an idea about the predevelopment test in new drug designing, its potential and future prospect.[3,5,9]