PHARMACEUTICAL STANDARDIZATION AND PRELIMINARY PHYSICO-CHEMICAL EVALUATION OF TRINAKANTAMANI BHASMA
Bhavin M. Chavda*, Dr. Bharat D. Kalsariya and Dr. Darshan K. Parmar
ABSTRACT
Bhasmikarana is process in which a substance which is bio-incompatible is converted into bio-compatible form by various Samskara. Marana of Ratna, Uparatna is not advised in Ayurveda. Trinakantamani Bhasma is well known formulation used by Ayurveda physician. Trinakantamani Bhasma was prepared by reference of Bheshaja Samhita, Bhasma-Pishti Prakarana,[1] which is indicated for Vataja, Pittaja and Kaphaja Galagraha, Gala Granthi, Gandamala. Total 10 pilot batches has been prepared to decide the quantum of heat and temperature at which Bhasma can be prepared. Three batches of Bhasma has been prepared in EMF by setting temperature at 230°C. Average liquid media (Punarnava Panchanga Svarasa, Adhahpushpi Panchanga Svarasa, Vijaysara Tvak Svarasa) used for Bhavana were 130,143 and 128 ml respectively. Average yield for three batches was 0.77 %. Time required to attain peak temperature was 20 minutes and for self-cooling 14 hours were required. Color was changed from light yellow to brownish yellow. Physico-chemical parameters for each batch of Trinakantamani Bhasma did not show any major changes in all the parameters.
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