World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

EFFECTS OF AQUEOUS STEM EXTRACT OF COSTUS AFER ON SOME BIOCHEMICAL1 PARAMETERS IN MALE ALBINO WISTAR RATS

Nwankpa Promise, Amanahu Lawrence Chinedu, *Uche Mercylyn Ezinne and Ekweogu Celestine Nwabu

ABSTRACT

Costus afer leave when chewed is used to treat severe dehydration and diabetes mellitus in South-East Nigeria. This study evaluated the effect of Costus afer aqueous stem extract on some biochemical parameters in male albino wistar rats. 20 male rats were divided into 4 random groups of 5 animals each and were treated as follows: group 1 (normal control); group II (50mg/kg of C. afer stem extract); group III (100mg/kg of C. afer stem extract); group IV (150mg/kg of C. afer stem extract). The liver, kidney and lipid profile assays were done using Randox Laboratory kits. Results showed a statistically significant increase (p 0.05) in the levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), high density lipoprotein (HDL) in treated animals when compared with normal control. There was no significant change (p 0.05) in the levels of creatinine in treated animals when compared with control. In conclusion, Costus afer stem extract is anti-lipidaemic but hepatotoxic and should be used with caution.

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