ANTIEPILEPTIC ACTIVITY OF CALOTROPIS PROCERA LINN FLOWERS
Madhulatha B., Shiva Nandini D., Meghana D., Madhulikha B. and Kotresh Yaligar*
ABSTRACT
The present study aimed to investigate the phytochemical screening and pharmacological evaluation of the ethanolic extract of Calotropis procera Linn. (EEFCP) and petroleum ether extract of the flower of Calotropis procera Linn. (PEFCP). The plant materials were collected, authenticated, and subjected to shade drying then made into coarse powder. The powder plant material is subjected to cold maceration and extracted with soxhlet apparatus by using ethanol (90%) & petroleum ether to get crude extracts. These extracts are subjected to preliminary phytochemical investigation and pharmacological evaluation of antiepileptic activity on Swiss albino mice. The acute toxicity studies were carried out to evaluate the drug’s toxicity and it shows toxicity at a dose of 4500 mg/kg b.w. The antiepileptic activity of flower extracts of Calotropis procera Linn. Was evaluated by using Maximum Electric Shock (MES) induced epilepsy & Chemical Induced Model (Strychnine Induced Epilepsy) in Swiss albino mice have been conducted at a dose of 100 mg/kg b.w which shows a significant level of *p
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