Abstract

Sachin Nath*, Dr. Govind Nayak, Dr. Abhishek Sharma, Dr. Mehta Parulben D.

ABSTRACT

To evaluate the pharmacological activity against diarrhea of ethanolic extract of Adenostemma Lavenia (Family: Asteraceae) leaves. The present study was undertaken to evaluate the effects of EEAL on castor oil-induced diarrhea and magnesium sulphate-induced diarrhea method were examined. Each model consisted five groups, normal control, disease control,standard (loperamide), Adenostemma Lavenia leaf extract 250 mg/kg and 500 mg/kg were used. It was noticed that the fecal weight was reduced in the doses 250 and 500 mg/kg significantly in comparison to control. The extract dose (300 mg/kg) was significantly chosen for reducing the diarrheal condition in experimental rats. The extract was found to inhibit peristaltic movements of secretions in castor oil induced and magnesium sulphate induced model confirming its antidiarrheal activity, which might be due to its high flavonoid content. The results provide evidence that the ethanolic extract of Adenostemma Lavenia leaf possesses antidiarrheal activity and could be accounted for pharmacological effects and Herbal medicine.