Abstract

Riyaz Ahmed Khan*, Md. Majid Iqbal, Md. Ateeq ur Rehman and Abedulla Khan Kayamkani

ABSTRACT

Glipizide is an oral quick and short acting anti diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enter hepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half lives than the first generation sulfonylureas. The rationale of this study was to enhance the solubility & dissolution of the Glipizide by preparing its complex with water soluble polymers such as PEG 4000 and PEG 6000 were selected as carriers. In the present study attempt has been made to prepare, formulate and characterize inclusion complexes of Glipizide with PEG 4000 and PEG 6000. The inclusion complexes were prepared by two methods viz. Physical method and Kneading method. The inclusion complex containing Glipizide: PEG 4000 and PEG 6000 were further formulated into Tablets by Direct Compression Technique using microcrystalline cellulose, Magnesium stearate and Aerosil. The prepared Tablets were characterized using FTIR and DSC and finally the prepared Tablets Were Evaluated for various pharmaceutical characteristics viz. Hardness, % Friability, thickness, Weight Variation, Drug Content and In-vitro Dissolution profiles. The results of stability studies revealed no change in physical appearance, hardness, thickness, drug content and in vitro dissolution profiles, thus indicating that formulation GF4 was stable.