Abstract

Stanislas Pendélakys Gbètognon Sèdagbandé*, Kamara Mandjou and Yomalan Kassi

ABSTRACT

Tectona grandis (Verbenaceae) is a plant commonly used in traditional African medicine to treat several diseases including anemia. The present study was carried out to evaluate the pharmacological effects of an aqueous extract of dry leaves of Tectona grandis (EATg) on induced anemia in wistar rats in order to contribute to the valorization of the use of plants used in traditional medicine. for improving the health of populations. Hemolytic anemia was induced by oral administration of phenylhydrazine hydrochloride at a dose of 8 mg/kg body weight for 10 days. The hematological parameters for diagnosing anemia were measured in each batch of rats using an automatic hematological analyzer (URIT 3000 PLUS). Daily oral administration of EATg, at doses of 100, 500 and 1000 mg/Kg of BW and Ranferon® for 14 days to anemic rats, restores or restores the number of red blood cells, the hemoglobin level, the hematocrit, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV) and mean corpuscular hemoglobin content (MCHC) deteriorated by phenylhydrazine. It appears from this study that EATg has anti-anemic properties similar to those of Ranferon®; which justifies its use in traditional medicine in the treatment of anemia.