Abstract

Addy P. S.*, Erigbali P. P. and Sule O. J.

ABSTRACT

Five (5) classes with five (5) rodents each were in experimental design to study impact of Persea americana’s seed extract on induced-nephrotoxicity. First group receiving animal feed and water ad libitum served for control, Group 2, positive control receiving 0.1ml/kg b.w of ethylene glycol for 7 days, Groups 3 and 4 served as treatment groups receiving 100mg/kg and 200mg/kg extract of Persea americana (EPA), twice daily for 21 days and 0.1ml/kg ethylene glycol (EG) for 7 days with continuation of the treatment of EPA and Group 5 received a reference drug of 0.2mg/kg Folic acid and 0.3mg/kg Thiamine (twice daily) for 21 days and 0.1ml/kg EG for 7 days with continues treatment of the reference drug. Nephroprotective effects of EPA was evaluated by estimating the activities of Urea, Creatinine and levels of total protein. The effects of EPA on biomarkers of oxidative damage (lipid peroxidation) and antioxidant enzymes namely, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were also measured in the kidney using homogenates of the organ. EPA and the reference drug used revealed nephroprotective action for reducing (p< 0.05) Urea with creatinine when compared to the positive control. Measures of oxidative stress bio-indicators were depleted along graded dose in EPA – administered animals. Conclusively, EPA may have proffered nephroprotection not unconnected with its antioxidative bioactivity.