World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

Login Register
World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

SJIF Impact Factor: 6.842

Abstract

DEVELOPMENT AND VALIDATION OF CILNIDIPINE AND METOPROLOL SUCCINATE IN BULK AND MARKETED FORMULATIONS BY UV SPECTROSCOPIC METHOD

Keerthana Shetty, Neeladri Srinivasulu, Yegnoor Anand Kumar*, Madhusri Chagi and Pooja Polkal

ABSTRACT

A specific, accurate, precise, robust, and cost-effective UV method was developed and validated for quantitative analysis of Cilnidipine (CLD) and Metoprolol Succinate (MTS) in alone and marketed dosage forms using Medium I (Methanol: Phosphate buffer pH 6.8 (3:1) as solvent blend. The λ max for CLD and MTS was found to be 242 nm and 223 nm respectively. Linearity was observed in the concentration range of 1-10 μg/ml for Cilnidipine and 1-10 μg/ml for Metoprolol Succinate. The accuracy of method was assessed by recovery studies and was found to be within acceptable range for both CLD and MTS. The developed Medium I was validated with respect to linearity, accuracy (recovery) and precision. The results were validated statistically as per ICH guidelines and were found to be satisfactory. The Medium I can be successfully applied for the determination of CLD and MTS in alone and marketed samples.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR