Abstract

Vitthal Gawade*

ABSTRACT

Ibuprofen is widely used as a prescription and non-prescription medicine. The aim of study is to prepare Ibuprofen tablets (400mg) using direct compression technique which is now days considered a cost effective and simple method of manufacturing. Compression of solid particle directly into tablets is the method of choice for the preparation of tablets. This method has several advantage such as, cost effective as it has less number of unit operation than wet granulation, highly adaptive for products and APIs sensitive to moisture and heat. Tablets prepared by direct compression method exhibit comparatively faster dissolution. The method of direct compression require excipients with good flow ability and compressibility.  Hence, this research work has been taken up with the purpose of developing a new, efficient and cost effective directly compressible vehicle for the preparation of tablets by direct compression method.