Abstract

Erigbali P. P.*, Joffa PPK, Kiridi E. G., Pughikumo D. T., Lelei S., Erigbali V T., Ndego H.O. and Oshemughen G.

ABSTRACT

The analgesic potential of 2,6-bis[(4-dimethylaminophenyl)methylidene]cyclohexan-1-one (A1) was investigated in mice model of thermal pain – induction; as part of research effort to ameliorate adverse and addictive proclivity of current pain regimens, while proffering effective relief. Randomly selected mice were placed in experimentally designed groups; and administered distilled water, A1 (in graded dose), and tramadol (as standard). Thereafter, all groups were subjected to thermally induced pain by hot plate and water bath methods, to understudy their Neurobehaviour associated with pain reaction and response time as a means of deciphering analgesic activity of those regimens. Observed data was analysed by one – tailed ANOVA and Dunnett’s test for statistical relevance. The results from the two models show that threshold for pain was significantly (p<0.0001) increased in the A1 and tramadol administered animals than control group, which implies A1 may potentially proffer pain relief, as standard regimen – tramadol does.