Abstract

Gordana Bukara-Radujkovic

ABSTRACT

Introduction: This study investigates the impact of sensor-augmented insulin pump therapy on thyroid-stimulating hormone (TSH), lipid profile, and glucose metabolism parameters in children with type 1 diabetes mellitus (T1DM) over a three-month period. Methods: A cohort of pediatric patients with T1DM undergoing sensor-augmented insulin pump therapy was monitored for changes in TSH, lipid profile, and continuous glucose monitoring parameters. Pearson correlation coefficients were calculated to assess associations between variables, and t-tests for paired samples were conducted to evaluate changes over time. Results: Our findings reveal a significant association between sensor-augmented insulin pump therapy and increases in TSH and total cholesterol, particularly in patients with initial HbA1c levels below 7.00%. Triglycerides exhibited significant correlations with time spent in normoglycemia and hyperglycemia, suggesting a link between glycemic control and lipid metabolism. Notably, thyroid hormones demonstrated associations with glucose control parameters, indicating potential interplay between thyroid function and glucose metabolism. Conclusion: These results underscore the importance of comprehensive metabolic monitoring in pediatric T1DM management, incorporating lipid status and thyroid function assessments alongside continuous glucose monitoring. Further research is warranted to elucidate these relationships and optimize metabolic control strategies in pediatric T1DM patients.