Abstract

Nabanita Mal*, Ashrubindu Bhunia and Dr. Beduin Mahanti

ABSTRACT

Controlled drug delivery systems have revolutionized the field of pharmaceutics by offering numerous advantages over conventional dosage forms. This project aims to provide a comprehensive overview of this pivotal technology, covering its historical development, terminologies, types, drug properties suitable for controlled release formulations, applications, advantages, and limitations. The introduction will underscore the significance of controlled drug delivery systems in optimizing therapeutic efficacy while minimizing adverse effects and improving patient compliance. The historical section will trace the evolution of these systems, highlighting the pioneers and key milestones that paved the way for their widespread adoption, including the development of biodegradable polymers and nanotechnology-based delivery platforms. Terminology related to controlled drug delivery systems will be elucidated, ensuring a clear understanding of terms such as sustained release, extended release, delayed release, and targeted delivery. The types of controlled drug delivery systems will be explored in-depth, encompassing oral, transdermal, parenteral, implantable, and novel approaches like microneedles and nanocarriers. Physicochemical properties of drugs suitable for controlled release formulations will be discussed, emphasizing factors like solubility, partition coefficient, molecular size, stability, and protein binding, which influence the selection and design of appropriate delivery systems. Applications will highlight controlled release medications across various therapeutic areas, such as cardiovascular diseases, diabetes, pain management, oncology, and neurological disorders, showcasing their potential to enhance patient outcomes and quality of life. Emerging applications in gene therapy and regenerative medicine will also be explored. The advantages, including improved bioavailability, reduced dosing frequency, sustained therapeutic levels, minimized side effects, and targeted delivery to specific tissues or cells, will be thoroughly explored. Conversely, the disadvantages, such as potential drug-excipient interactions, complex manufacturing processes, higher costs, and regulatory challenges, will be addressed objectively. By providing a comprehensive understanding of controlled drug delivery systems, this project aims to equip readers with valuable knowledge that can foster innovation, optimize therapeutic strategies, and ultimately contribute to better patient care and quality of life.