World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

Login Register
World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

SJIF Impact Factor: 6.842

Abstract

ASSESSMENT OF LONG NON-CODING RNA LNC-RP11-697E AND ITS TARGET Hepatocyte Nuclear Factor 1 AS PREDICTORS TO CISPLATIN- RESISTANCE IN OVARIAN CANCER

Noha Ahmed Abdel Rahman, Nashwa El-Khazragy, Mohamed M. Naguib and Marwa G. A. Hegazy*

ABSTRACT

The current study aimed to investigate the prediction utility of the long noncoding RNA (lnc-RP11_697E) and its target gene, hepatocyte nuclear factor 1β (HNF-1β) to Cisplatin-resistance in patients with ovarian cancer (OC), in addition, to assess their diagnostic significance. The expression levels of lnc-RP11-697E and HNF-1β were assessed in 25 formalin-fixed paraffin-embedded tissue (FFET) samples from OC patients who were treated with intravenous Cisplatin-based chemotherapy and 25 healthy ovarian (non-cancerous) tissues as the control group using qPCR. The results revealed that lnc-RP11-697E was significantly overexpressed, while HNF-1β was downregulated in Cisplatin-resistant tissues. In addition, lnc-RP11-697E and its target HNF-1β exhibited high sensitivity and specificity in predicting Cisplatin-resistance and in differentiating ovary cancer from controls. The tissue expression levels of lnc-RP11-697E and its target HNF-1β could be used as diagnostic biomarkers for OC and as predictors for Cisplatin-resistance in patients suffering from OC.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR