Abstract

Sachin Bhusari*, Aishwarya Musande and Pravin Wakte

ABSTRACT

This study aims to develop and validate an analytical method for the estimation of Glycolic Acid in hydrogel face mask formulations. Utilizing spectrophotometric analysis, the method ensures precise quantification and stability of Glycolic Acid, a widely used alpha-hydroxy acid in skincare products. Various formulations were prepared with different concentrations of sodium alginate and xanthan gum to optimize the hydrogel matrix. The formulations were thoroughly evaluated for their physical characteristics, pH, drug content, in vitro drug release, and stability. The physical appearance of the formulations was transparent with a smooth texture, and the pH values were near neutral, minimizing the risk of skin irritation. Drug content analysis confirmed consistent Glycolic Acid levels, while in vitro drug release studies demonstrated a controlled release profile, with the optimized formulation achieving 82.43% release at 25 minutes. Stability studies, conducted under ICH guidelines, indicated no significant changes in appearance, pH, texture, or odour over a 30-day period. The optimized formulation, F3, exhibited a pH of 5 ± 2, good texture, and a drying time of 15.8 ± 0.29 minutes. The results confirm that the hydrogel face mask containing Glycolic Acid is stable, with desirable physical characteristics, making it suitable for cosmeceutical applications. This validated method provides a reliable tool for the quality control of Glycolic Acid in hydrogel formulations, ensuring product efficacy and safety for consumer use.