A COMPREHENSIVE REVIEW ON THE MECHANISM OF ACTION IN PEPTIC ULCER PATHOGENESIS
Shubham Anand,*, Namrata Mishra, Manoj Kumar Bajhaiya, Nisha Verma, Surendra Rajdhar, Aman Sharma, Anand Singh Rajput
ABSTRACT
Background Up to 10% of people worldwide suffer with peptic ulcer disease, making it a common yet serious chronic condition. Peptic ulcers develop when stomach juice pH is high and mucosal defences are weakened. Both the infection with Helicobacter pylori (H.) and nonsteroidal anti-inflammatory medicines (NSAIDs) have been linked to decreased mucosal resilience to damage. Main body of the abstract Internal gastrointestinal (GI) disruption due to the production of gastric acid or pepsin is what defines peptic ulcer disease (PUD). The stomach and the first part of the duodenum are common sites for the phenomenon. The jejunum, distal duodenum, and lower oesophagus might be affected. Patients with gastric ulcers often have epigastric discomfort 15-30 minutes after eating, whereas those with duodenal ulcers suffer pain 2-3 hours after eating. Short Conclusion Side effects, relapses, and medication interactions have been reported with peptic ulcer therapies such as proton pumps inhibition chemicals and histamine (H2) receptor inhibitor molecules. However, the chemical compounds found in medicinal plants may be used to cure and prevent various illnesses. Therefore, in this analysis, we will look at some of the most often used medicinal plants for peptic ulcers and how they may be put to use in these capacities.
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