AN INSIGHT ON DRUG-INDUCED HEPATOTOXICITY W.R.T. GARAVISHA AND IT’S AYURVEDIC MANAGEMENT
Dr. Anagha B. V.*, Dr. Saran Babu and Dr. Vikram S.
ABSTRACT
Liver is a vital organ involved in metabolism of nutrients, detoxification of drugs and xenobiotics by Drug Metabolizing Enzymes to maintain homeostasis. Liver insufficiency and drug induced hepatotoxicity are the major causes of liver disease and death worldwide. In Ayurveda, Garavisha are explained as artificial poisons prepared by mixing various substances, that takes time to get metabolised and produce toxicity in the long run. This may be prevented and managed by the usage of Yakrit Rogahara, Kamalahara, Yakrit Vriddhihara Dravyas which act as hepatoprotective agents. In this paper, an attempt is made to co-relate drug-induced hepatotoxicity to Garavisha, along with the description of a few classes of allopathic drugs, their mechanisms, and a few examples of Ayurvedic Audbhida (Ekamulika Dravyas) and Parthiva/Bhauma Dravya like Dhatu Bhasmas having hepatoprotective action.
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