World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

FORMULATION AND EVALUATION OF SEMI- INTERPENETRATING POLYMER NETWORK MICROSPHERES OF ANTIANGINAL DRUG USING DELONIX REGIA GUM

Ashwini B. Meshram*, Neha D. Meshram, Nikita R. Nandanwar

ABSTRACT

The goal of the current project is to develop semi-IPN microspheres of Nicorandil using Chitosan and delonix regia gum by emulsion cross-linking method. Nicorandil was chosen as a model drug. DRG-Semi-IPN microspheres were prepared at varying speed from which 3000rpm was found to be optimum. The drug was loaded into beads by varying their composition such as, amount of crosslinker glutaraldehyde and ratio of chitosan. Glutaraldehyde was used as a cross-linker at varying concentrations 2,4,6ml in which 4 ml was selected as optimum. A total of nine batches were prepared by varying the polymer blend ratio and by using glutaraldehyde as a cross-linking agent. The prepared microspheres were subjected for various evaluation parameters such as Drug content, % Entrapment efficiency, Swelling behavior, and in-vitro release study. From the results, batch F5 was selected as the optimized batch as it showed 94.55% drug release, and 87.0% entrapment efficiency, and the optimized batch was evaluated using FTIR, SEM, and stability study. The stability studies were carried out on optimized formulation F5 at 400 C± 20 C and 75% ± 5% RH for three months. The microspheres were evaluated for percent drug loading, percent drug entrapment efficiency and percent cumulative drug release for 0, 30, 60, and 90 days. No significant changes in percent drug loading, percent drug entrapment efficiency, and drug release were obtained and hence it was concluded that the optimized batch (F5) was stable.

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