IBUPROFEN INDUCED STEVEN JOHNSON SYNDROME
Manasa Bollampally*, Gaddam Praneeth and Ambati Prithi
ABSTRACT
Stevens Johnson Syndrome (SJS) is a hypersensitivity reaction characterized by skin rashes with hyperpigmentation and cutaneous target lesions involving blistering/erosions over face, trunk & limbs. The mortality rates of SJS/Toxic Epidermal Necrolysis (TEN) is ranging between 10% and 75 %. Nonsteroidal antiinflammatory drugs (NSAIDs), analgesic agents and nonsulfonamide antibiotics are associated with SJS/TEN is controversial.[5] Case report: A 2years old male child was admitted in hospital with chief complaints of swelling, discolouration of lips and skin lesion since 4 days. Flexon suspension (ibuprofen 100mg+ paracetamol 125mg) was used for fever. The condition was managed with Intravenous fluids, oral corticosteroids prednisolone, fusidic cream and liquid paraffin. Conclusion: Early identification and discontinuation of the causative drug is very important as it helps to avoid secondary infection and other complications.
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