Abstract

Jyoti Bhushan Khedekar*, Swati Laxman Khedekar and Pooja Radhakrushna Gawandar

ABSTRACT

The aim of present study was to explore feasibility of polymer in acquiring the drug release profile, floating drug delivery system of Metoprolol Succinate for treatment of hypertension. The drug excipints compatibility study was done by using IR the characteristics Peaks of Metoprolol Succinate with polymers & other excipients was identified. The pre-formulation study of raw material and powder blend were carried out and drug and all excipient showed optimum result. The Tablet of Metoprolol Succinate was prepared by using various synthetic with varying Concentration, evaluated for necessary parameters including Weight variation, friability, Hardness & drug content. It was observed that the results were in considerably good range. The percentage swelling index of all formulation was determined and it was observed that combination batches of polymer showed better swelling than single polymer formulation. The In-vitro drug release study was carried out in dissolution medium PH 6.8 Phosphate Buffer, the percentage drug release obtained in formulation S1,S2,S3 are decreased while in formulation S4 is increased in which concentration of Sodium Alginate to HPMC K100 is 1:2 ratio. The drug release of polymer combined formulation showed synergistically better result than formulation with single polymer. The combination in 1:2 ratio showed better release profile.