EXPLORING THE BIOLOGICAL FRONTIERS: SYNTHESIS AND EVALUATION OF CURCUMIN-AMINO ACID CONJUGATES
Lovy Sharma* and Gaurav Chaudhary
ABSTRACT
Curcumin is a phytochemical derived from the rhizomes of curcuma longa, having a wide varieties of therapeutics effects such as anti-diabetics, anti-inflammatory, anti-oxidant, in asthma, anti-cancer, anti-viral, anti-amyloid, as neuroprotective, in cardiovascular diseases, in cardio toxicity, in arthritis, anti-septic, anti-bacterial, in peptic ulcer. Apart form these theraeutics effects there are some drawbacks associated with curcumin such as unstability, poor water solubility, less bioavailability, poor absorption, which restrict the therapeutic response of curcumin. In this work, we designed the curcumin-amino acids conjugates via modification on phenolic group of curcumin without disturbing the methoxy group, with the aim to achieve the goal of implementing certain desirable characteristics in curcumin, such as reduced side effects, increased bioavailability, and therapeutic potential in order to determine antibacterial and anti-inflammatory activity of synthesised conjugates. All the synthesized derivatives of curcumin (L1 to L6) exhibited moderate to significant biological activity in terms of anti-inflammatory and anti-bacterial activity. It may be concluded that principles of structural manipulation have been appropriately applied in the present research work. This structural manipulation may lead to the synthesis of amino acid derivates of curcumin may serve the purpose of obtaining desirable therapeutic activity, minimization of side effects and desirable changes in the properties like solubility, bioavailability and stability to the chemical structure.
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