World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

Abstract

GOUT: UNVEILING THE COMPLEX INTERPLAY BETWEEN PATHOPHYSIOLOGY, EPIDEMIOLOGY, GENETICS, AND THERAPEUTIC OPTIONS - A COMPREHENSIVE REVIEW

Sethuramani A.*, Ajith P., Chandrasamy M., Raxshiya Smily J., Safia farvin S. and Sedhulakshmi K.

ABSTRACT

Gouty arthritis, one of the earliest known diseases, was first identified by the Egyptians around 2640 BC. Known as 'the unwalkable disease' by Hippocrates, gout is linked historically to the consumption of rich foods and alcohol, grossing it the name 'the disease of kings'. Gout results from monosodium urate (MSU) crystals accrued due to elevated serum uric acid (SUA) levels. Although hyperuricemia is the primary cause, only a marginal with high uric acid levels ripens gout. Hyperuricemia ascends from amplified fabrication or declined seepage of uric acid, allied with circumstances like metabolic syndrome and cardiovascular disease. Pathophysiology of gout encompasses genetic insights with SLC2A9 and ABCG2 and, metabolic causes like an interruption of the xanthine oxidase enzyme activation and synthesis, and inclined levels of triglycerides are in concert with momentous roles. Common treatments include NSAIDs, corticosteroids, and medications to reduce uric acid levels, though these have side effects. There is growing interest in herbal medicines for gout, as some plants can act as xanthine oxidase inhibitors with fewer side effects.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR