TRANSDERMAL PATCH FORMULATION WITH NIGELLA SATIVA EXTRACT FOR SYNERGISTIC ANTI-BACTERIAL AND ANTI-INFLAMMATORY THERAPY
Silpa G.*, Aysumma C. U. and Gowrishankar N. L.
ABSTRACT
The objective of the present project was to extract Nigella sativa L. seed and incorporate it into a transdermal drug delivery system. Extraction was done with 100 ml of ethanol in a Soxhlet apparatus. The ethanol extract of Nigella sativa has antibacterial and anti-inflammatory activity. Hence, this extract was used for phytochemical screening and as an anti-bacterial and anti-inflammatory Phytoconstituent. An albumin degradation and protein denaturation method demonstrates anti-inflammatory activity. Six patches are formulated by using two solvent systems: water and EtOH, and HPMC 50CPS, along with PEG-400 10% w/v polymer weight by solvent evaporation technique, were suitable for good flexibility and elasticity. It was found that the formulations F3 and F4 (HPMC4%) have achieved acceptable mechanical properties and extended-release, prolonged zero-order release, and first-order kinetics, as well as regression values.
[Full Text Article] [Download Certificate]