Abstract

Ms. Mital Patel, Drashti Shah*, Manya Trivedi, Jhanvi Gohil, Rutvi Patel, Khushi Patel, Nazneen Vohra

ABSTRACT

Dandruff is a prevalent scalp condition that remains challenging to completely eliminate with conventional chemical treatments. In an effort to address this, a polyherbal anti-dandruff hair gel was formulated and systematically evaluated for stability and quality. The study focused on synthesizing an herbal gel using ethanolic extracts of Zingiber officinale (ginger) rhizomes and Moringa oleifera (moringa) leaves, carefully combined in predetermined proportions with suitable excipients. The formulation was designed to provide effective anti-dandruff treatment with improved safety and minimal side effects compared to synthetic alternatives. The gel was subjected to a comprehensive evaluation, including phytochemical screening to confirm the presence of bioactive compounds, physicochemical characterization to assess consistency, spreadability, pH, and viscosity, as well as antimicrobial and anti-dandruff activity assays. The antidandruff efficacy was assessed against Malassezia furfur, the primary causative agent of dandruff. Additionally, antimicrobial studies were conducted to evaluate the gel's activity against Klebsiella pneumoniae and Staphylococcus aureus, two common pathogenic microorganisms. Stability testing was performed over a 30-day period under controlled conditions to assess the gel's ability to retain its physical properties and therapeutic efficacy. The results indicated that the polyherbal gel exhibited favorable physicochemical properties, maintained its structural integrity, and remained stable throughout the study period. Furthermore, the gel showed significant anti-dandruff activity, with notable inhibition of Malassezia furfur growth, alongside promising antimicrobial effects against K. pneumoniae and S. aureus. In conclusion, the polyherbal anti-dandruff gel demonstrated both effective anti-dandruff and antimicrobial properties, making it a viable natural alternative to conventional treatments. Its stable formulation and beneficial therapeutic properties suggest its potential for further development and use in managing dandruff and associated scalp conditions.