Abstract

A REVIEW ON RECENT ADVANCEMENT IN THE MANAGEMENT OF RHEUMATOID
ARTHRITIS

ABSTRACT

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which causes pain and disability. New developments in its treatment have greatly changed the current understandings and shifted towards preclinical intervention and personalized treatments. Summary this review provides an update of the recent therapeutic advances including targeted biologic agents like TNF inhibitors and IL-6 antagonist, which have drastically improved patient function. Moreover, because of their oral availability and effectiveness in individuals who do not respond to standard therapeutics, Janus kinase (JAK) inhibitors have emerged as additional viable options. In addition to pharmacotherapy, there has been a trend toward the integration of physical therapy (PT), nutritional support and patient education into practice in an MD care model with regards increased quality-of-life. As a phase I study, investigators caution that the results are preliminary and need to be validated prospectively in larger cohorts while advising additional research on biomarkers as well as personalized medicine will help create more targeted intervention programs tailored specifically for the individual. The article highlights the importance of these developments in changing how RA is managed and moving toward a more comprehensive view that involves treating symptoms as well as improving overall health over time. Further research and collaborative efforts are needed in order to continue working towards improved care of patients with RA.