CHEMICAL CONSTITUENTS OF RAZAFIMANDIMBISONIA MINOR (BAILL.) KAINUL & B. BREMER, AERIAL PARTS, RUBIACEAE OF MADAGASCAR
Henintsoa Rakotoarivelo, Faliarivony Randriamialinoro, Mahefarivo Andrianjakaniaina, Reine Dorothée Ramilison Razafimahefa, Dimby Andrianina Ralambomanana* and Sylvia Tiana Ralambonirina Rasoarivelo
ABSTRACT
Traditional medicine uses the aerial parts of Razafimandimbisonia minor (Rubiaceae), a species endemic to Madagascar, to treat liver disorders and fatigue, diseases associated with oxidative stress. A phytochemical analysis of this plant made to isolate, by chromatography, six compounds: vanillin, ursolic acid, and oleanic acid were identified in the leaf extracts, while stigmasterol, (-) - epicatechin, and fraxin were extracted from the stems. These compounds are isolated for the first time from the aerial parts of this plant. Their structure was confirmed by NMR spectroscopy and compared to existing data in the literature. According to previous research, some of these compounds have antioxidant properties.
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