Abstract

Anjan Gowda C. R.* and Sudha B. S.

ABSTRACT

The present study was carried out with the aim of development and optimization of multi particulate drug delivery system of Metformin loaded microsponges for controlled drug delivery, targeting diabetes management and localized anti-inflammatory effects. Using the quasi-emulsion solvent diffusion method, microsponges were formulated with ethyl cellulose and Eudragit RS 100 as retardant polymers, and process parameters were optimized through variations in polymer types and concentrations, stirring speeds, and ratios of active pharmaceutical ingredient (API) to polymer for controlled release. Among the formulations, F8 showed the highest drug content (85.57% entrapment efficiency) and sustained in vitro release (87.83%). This optimized formulation was incorporated into a topical gel, exhibiting favourable properties such as ideal viscosity, pH, and spreadability. The findings highlight the potential of Metformin microsponges in achieving dual therapeutic benefits through sustained, localized, and systemic delivery, offering a novel approach for managing diabetic complications.