NANO-EMULGEL AS CARRIER FOR TOPICAL DRUG DELIVERY OF ETORICOXIB- FORMULATION AND EVALUATION
Yashaswini M.R.* and Sudha B.S.
ABSTRACT
The present study aimed to formulate and evaluate Etoricoxib nanoemulgel for topical treatment of pain associated with rheumatoid arthritis. Etoricoxib nanoemulsion was prepared by using a high-energy method. Optimized Etoricoxib nanoemulsion was off-white with particle size, PDI, zeta potential, and drug content values of 98.3±0.3 nm, 0.45±0.01, 29.7±0.85 mV, and 97.9±0.35%, respectively. F9 exhibits the highest drug release of 99.63% after 12 hours compared to other nanoemulsion. 1% Carbopol 940 gel was selected best due to low viscosity and high spreadability. Prepare and evaluate Optimized nanoemulsion, was incorporated into an optimized gel in a 1:1 ratio. The invitro drug release studies of nanoemulgel show the highest drug release compared to marketed products and follow zero-order kinetics, with drug release mechanism swelling and diffusion (anomalous transport non-Fickian mechanism). The results indicate that the developed Etoricoxib nanoemulgel is a promising topical delivery system for treating pain associated with rheumatoid arthritis.
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