World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

IMPACT OF LNC RNA-NEAT1 ON MULTIPLE DRUG RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA

Alya Ezzat Mohammed*, Magdy Mahmoud Mohamed, Nashwa Nagy El Khazragy and
Nour Mohamed Abd El-Kader

ABSTRACT

The biological impact and therapeutic potential of long non-coding RNAs (lncRNAs) in chronic lymphocytic leukemia (CLL) remain an area of concern and research. Many studies have found that lncRNAs play a role in cancer progression as well as chemotherapy resistance. Herein, we investigated the impact of lncRNA NEAT1 on multiple drug resistance in CLL. We examined NEAT1 expression in B-CLL patients and in normal B-cells. This study aimed to determine the NEAT1 expression and its correlation with multiple-drug resistance (ATP-binding cassette transporter A3 ABCA3) gene expression in CLL patients using quantitative real-time polymerase chain reaction (qRT-PCR). Our results showed that NEAT1 expression was significantly lower in CLL patients compared to healthy controls (P-value = 0.016). Our results also showed a significant correlation between the expression levels of NEAT1 and ABCA3 genes in CLL patients (P-value < 0.05).

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