ISOLATION AND STRUCTURAL ELUCIDATION OF THREE NEW COMPOUNDS CARISSININDOLE, SPININDOLE-A AND SPININDOLE-B FROM THE LEAVES OF CARISSA SPINARIUM (APOCYNACEAE) ORIGINATED FROM MADAGASCAR
Fiatoa Barthelemy*, Ralaivaon-Dratsitonta Jumael Edith Fabrice, Tiandreny Hazara Jipaty, Rainimanantsoa Jenosusbel, Ratsimavo Jacque Chrysologue and Fatiany Pierre Ruphin
ABSTRACT
From the leaves of Carissa spinarium (Apocynaceae), a medicinal plant species endemic to Madagascar, three new compounds typical of Indolomonoterpenic alkaloids compounds named Carissinindole, Spinindole-A and Spinindole-B containing three membered rings in its side chain were isolated by repeated silica gel column chromatography. Their structures were determined by 1D and 2D NMR spectroscopy and spectroscopy High-resolution MS-IES. The results of the present research work is reported for the first time and revealed that a comparative study of the Apocynaceae family will help to understand the origin and maintenance of diversity among this family and their implication at Pharmacognosy level (biotaxonomy).
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