Abstract

Priyanka Raj G.*, Ranjeetha A. R.*, Aishwarya K. S., Ananya M. S. and Anjana N. K.

ABSTRACT

The purpose of this work was to develop a novel topical formulation of econazole nitrate based on gel that can be easily scaled up in one pot for the potential treatment of fungal and yeast infections. Econazole nitrate is a topical antifungal, is used to treat tinea versicolor, tinea pedis, and tinea cruris. Compared to applying cream or ointment, topical gels offer numerous advantages, one of which is that the drug is released more quickly to the intended site of action. A viscous mixture of propylene glycol, Triethanolamine, methyl paraben, and econazole nitrate were mixed together before being formulated into the optimized gel bases. The gel’s color, appearance, and homogeneity were assessed visually. For every formulation, the drug content, pH, viscosity, spreadability, and gel strength were characterized. The manufactured formulations were transparent, half white, pale yellow, and exhibited excellent homogeneity. The pH and viscosity are in within the limit. The drug diffusion of F1 93.81, F2 97.56, F3 92.36, F4 90.95, F5 93.18, and F6 90.14 .From among all the developed formulation, F2 shows better drug diffusion that is 97.56.