RESEARCH ON ENHANCEMENT OF FORMULATION EFFICACY FOR MCC PELLETS USING ACECLOFENAC AND ACETAMINOPHEN API
Shobhit K. Suralke* and Neha Madavi
ABSTRACT
MDDS consists of two layers of drug differentiated by a layer of extended-release polymer. The system consists of water-insoluble pellets on which the drug is coated and to control the release rate of that drug the extended-release polymer such as ethylcellulose is coated. To control the rate of drug release a pore-forming agent like HPMC is incorporated along with ethylcellulose and another drug was coated over the layer of extended-release coating for the immediate release. As the system comprises of two different drugs and an extended-release polymer this system brings the advantage of formulation of incompatible drug that may be intended to be given at the same time along with that due to extended-release coating this may also help to control the release rates of drugs for the treatment of Analgesic and Antipyretic activity multilayer pellets were coated using polymers such as Ethylcellulose, and Hpmc.
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