Abstract

Ratnesh Kumar* and Ishika Jain

ABSTRACT

Psoriasis is a prevalent auto immune disease that affects the skin and joints, mostly affecting T cells and resulting in inflammation. It is an autoimmune-based, long-term inflammatory skin illness associated with psoriatic arthritis, mental, cardiovascular, and hepatic issues. Ten percent of patients have preventable psoriasis vulgaris, a condition with a superposed clinical makeup that comprises chronic plaque lesions. These people also get arthritis. In the bone marrow,T-lympocytes arises from a common lymphoid progenitor that also gives rise to B lymphocytes. Following that, T cells leave the bone marrow and travel to the thymus gland to begin developing; it is at the thymus where T cells acquire their moniker. When cytokines released by T cells were examined on the skin (epidermal specimen) of psoriatic patients, it was found that only a small percentage of cells secreted Th-2 related cytokines (IL-4 and IL-10). Whereas TNF-α, IL-2 and IFN-γ are Th1-related cytokines that are produced by almost all T cells.It is further suggested that through a complicated interaction between CD4+, CD8+T cells, and cross-presenting dendritic cells, CD8+ T cells are involved in the regulation of the Th1 polarization that is seen in psoriasis lesions.when a hyperactive immune system that targets healthy cells while attacking and producing an excessive number of skin cells is the cause ofpsoriasis. Genetics is important when one parent has psoriasis.Based on the information currently available, psoriasis mayrun in families and maybe influenced bygenetics. However, getting psoriasis is not a given just because a family member has it.People with psoriasis often develop the condition between the ages of 15 and 30, according to the National Psoriasis Foundation (NFP).Additionally, if you have a parent with psoriasis, your chances of getting the condition are increased by 28%.If one or both of your parents have the condition, your risk rises to 65%.Heart disease, metabolic syndrome, and dyslipidemia are prevalent health problems that impact the heart and blood vessels. Heart and blood vessel issues may be apparent since birth, including irregular heart rhythms and abnormalities in heart valves. Metabolic syndrome is a cluster of five disorders that may result in cardiovascular issues, stroke, and various health complications. Psoriasis, a condition linked to type 2 diabetes, is more prevalent among individuals with type 2 diabetes, leading to difficulties in insulin hormone production and utilization by the body. Diabetes is a multifactorial disease caused by a combination of genetic and environmental factors. Psoriasis involves inflammation in the gastrointestinal lining, which results in higher absorption of fats. The severity and location of skin affected determine the treatment for psoriasis.